Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi.

• Main Authors: Christopher S Eickhoff (Author), Jose R Vasconcelos (Author), Nicole L Sullivan (Author), Azra Blazevic (Author), Oscar Bruna-Romero (Author), Mauricio M Rodrigues (Author), Daniel F Hoft (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunization of mice with the Trypanosoma cruzi trans-sialidase (TS) gene using plasmid DNA, adenoviral vector, and CpG-adjuvanted protein delivery has proven highly immunogenic and provides protection against acute lethal challenge. However, long-term protection induced by TS DNA vaccines has not b...