Schistosome eggs stimulate reactive oxygen species production to enhance M2 macrophage differentiation and promote hepatic pathology in schistosomiasis.

• Main Authors: Yanxiong Yu (Author), Junling Wang (Author), Xiaohong Wang (Author), Pan Gu (Author), Zhigang Lei (Author), Rui Tang (Author), Chuan Wei (Author), Lei Xu (Author), Chun Wang (Author), Ying Chen (Author), Yanan Pu (Author), Xin Qi (Author), Beibei Yu (Author), Xiaojun Chen (Author), Jifeng Zhu (Author), Yalin Li (Author), Zhijie Zhang (Author), Sha Zhou (Author), Chuan Su (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis is a neglected tropical disease of public health concern. The most devastating pathology in schistosomiasis japonica and mansoni is mainly attributed to the egg-induced granulomatous response and secondary fibrosis in host liver, which may lead to portal hypertension or even death of...