Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration

• المؤلفون الرئيسيون: Yusuke Hatakawa (مؤلف), Akiko Tanaka (مؤلف), Tomoyuki Furubayashi (مؤلف), Rina Nakamura (مؤلف), Motomi Konishi (مؤلف), Toshifumi Akizawa (مؤلف), Toshiyasu Sakane (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2021-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

We have recently reported Catalytides (Catalytic peptides) JAL-TA9 (YKGSGFRMI) and ANA-TA9 (SKGQAYRMI), which are the first Catalytides found to cleave Aβ42. Although the Catalytides must be delivered to the brain parenchyma to treat Alzheimer's disease, the blood-brain barrier (BBB) limits the...