Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation

• Main Authors: M Herman Chui (Author), Ciyu Yang (Author), Nikita Mehta (Author), Vikas Rai (Author), Ahmet Zehir (Author), Amir Momeni Boroujeni (Author), Marc Ladanyi (Author), Diana Mandelker (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract TP53 is one of the most ubiquitously altered genes in human cancer. The biological impact of rare variants, particularly those located within noncoding regions, remains poorly understood. From interrogation of clinical massively parallel sequencing data from over 55,000 tumors, which includ...