Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells

• Main Authors: Marisol Estrella Armijo (Author), Emilia Escalona (Author), Daniela Peña (Author), Alejandro Farias (Author), Violeta Morin (Author), Matthias Baumann (Author), Bert Matthias Klebl (Author), Roxana Pincheira (Author), Ariel Fernando Castro (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheb is a small GTPase member of the Ras superfamily and an activator of mTORC1, a protein complex master regulator of cell metabolism, growth, and proliferation. Rheb/mTORC1 pathway is hyperactivated in proliferative diseases, such as Tuberous Sclerosis Complex syndrome and cancer. Therefore, targe...