CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline

• Main Authors: Yazhou Guo (Author), Chen Yang (Author), Rong Guo (Author), Ruijie Huang (Author), Yongxia Su (Author), Shuai Wang (Author), Yezi Kong (Author), Jianguo Wang (Author), Chengjian Tan (Author), Chonghui Mo (Author), Chenchen Wu (Author), Baoyu Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monocrotaline (MCT), a pyrrolizidine alkaloid, is the major toxin in Crotalaria, which causes cell apoptosis in humans and animals. It has been reported that the liver is a vulnerable target of MCT. However, the exact molecular mechanism of the interaction between endoplasmic reticulum (ER) stress a...