Population Pharmacokinetic Modelling and Simulation to Determine the Optimal Dose of Nanoparticulated Sorafenib to the Reference Sorafenib

• Main Authors: Ki-Young Huh (Author), Se-jung Hwang (Author), Sang-Yeob Park (Author), Hye-Jung Lim (Author), Mir-yung Jin (Author), Jae-seong Oh (Author), Kyung-Sang Yu (Author), Jae-Yong Chung (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sorafenib, an oral multikinase inhibitor, exhibits a highly variable absorption profile due to enterohepatic reabsorption and poor solubility. SYO-1644 improved the solubility of sorafenib by nanoparticulation technology leading to enhanced bioavailability. To evaluate the pharmacokinetically equiva...