Zerumbone reduces TLR2 stimulation-induced M1 macrophage polarization pattern via upregulation of Nrf-2 expression in murine macrophages

• Main Authors: Marwa Qadri (Author), Zenat Khired (Author), Reem Alaqi (Author), Sandy Elsayed (Author), Abdulaziz Alarifi (Author), Rayan Ahmed (Author), Hussain Alhamami (Author), Amani Khardali (Author), Walaa Hakami (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperuricemia contributes significantly to gout arthritis pathogenesis, which promotes urate crystal deposition in the joints and activates joint-resident macrophages and circulating monocytes to initiate a state of inflammatory arthritis. In the joint, macrophages have an immune defense role where...