Antihypertensive Effect of a Novel Angiotensin II Receptor Blocker Fluorophenyl Benzimidazole: Contribution of cGMP, Voltage-dependent Calcium Channels, and BKCa Channels to Vasorelaxant Mechanisms

• Main Authors: Hina Iqbal (Author), Amit Kumar Verma (Author), Pankaj Yadav (Author), Sarfaraz Alam (Author), Mohammad Shafiq (Author), Divya Mishra (Author), Feroz Khan (Author), Kashif Hanif (Author), Arvind Singh Negi (Author), Debabrata Chanda (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The current study presents the novel angiotensin II receptor blocker fluorophenyl benzimidazole (FPD) as an antihypertensive agent in the SHR model of hypertension. We investigated the role of cGMP, voltage-dependent L-type calcium channels, and BKCa channels in the vasorelaxant mechanis...