Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux

• Main Authors: Weijian Hang (Author), Benhong He (Author), Jiehui Chen (Author), Liangtao Xia (Author), Bing Wen (Author), Tao Liang (Author), Xu Wang (Author), Qianying Zhang (Author), Yue Wu (Author), Qingjie Chen (Author), Juan Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Type II diabetes (T2D)-induced cardiomyocyte hypertrophy is closely linked to the impairment of mitochondrial function. Berberine has been shown to be a promising effect for hypoglycemia in T2D models. High glucose-induced cardiomyocyte hypertrophy in vitro has been reported. The present...