Novel Functions of Ubiquitin Ligase HRD1 With Transmembrane and Proline-Rich Domains

• Main Authors: Tomohiro Omura (Author), Masayuki Kaneko (Author), Masayuki Onoguchi (Author), Shinobu Koizumi (Author), Miho Itami (Author), Mariko Ueyama (Author), Yasunobu Okuma (Author), Yasuyuki Nomura (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human ubiquitin ligase HRD1 is involved in endoplasmic reticulum-associated degradation (ERAD). We recently reported that HRD1 interacts with Parkin-associated endothelin receptor-like receptor (Pael-R), a substrate of Parkin, and promotes Pael-R degradation, resulting in the protection of cells fro...