HDAC4 Is Indispensable for Reduced Slow Myosin Expression at the Early Stage of Hindlimb Unloading in Rat Soleus Muscle

• Egile Nagusiak: Inna I. Paramonova (Egilea), Natalia A. Vilchinskaya (Egilea), Boris S. Shenkman (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

It is well known that reduced contractile activity of the main postural soleus muscle during long-term bedrest, immobilization, hindlimb unloading, and space flight leads to increased expression of fast isoforms and decreased expression of the slow isoform of myosin heavy chain (MyHC). The signaling...