Development of a sensitive and rapid method for quantitation of (S)-(â)- and (R)-(+)-metoprolol in human plasma by chiral LCâESIâMS/MS

• Main Authors: Primal Sharma (Author), Pritesh Contractor (Author), Swati Guttikar (Author), Daxesh P. Patel (Author), Pranav S. Shrivastav (Author)
• Format: Book
• Published: Elsevier, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A selective, sensitive and high throughput liquid chromatography-tandem mass spectrometry (LCâESIâMS/MS) method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2 (250mmÃ4.6mm, 5μm) column. Solid phase extraction of (S)-(â)- and (R)-(+)-metoprol...