Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates

• Autores principales: Anjong Florence Tikum (Autor), Anand Krishnan Nambisan (Autor), Jessica Pougoue Ketchemen (Autor), Hanan Babeker (Autor), Musharraf N. Khan (Autor), Emina E. Torlakovic (Autor), Humphrey Fonge (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that bind to different epitopes of domain III of EGFR. We developed ⁸⁹Zr-matuzumab as a PET probe for diagnosis/monitoring of response to treatment of a noncompeting anti-EGFR nimotuzumab antibody drug conjugate (AD...