Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates

• Auteurs principaux: Anjong Florence Tikum (Auteur), Anand Krishnan Nambisan (Auteur), Jessica Pougoue Ketchemen (Auteur), Hanan Babeker (Auteur), Musharraf N. Khan (Auteur), Emina E. Torlakovic (Auteur), Humphrey Fonge (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that bind to different epitopes of domain III of EGFR. We developed ⁸⁹Zr-matuzumab as a PET probe for diagnosis/monitoring of response to treatment of a noncompeting anti-EGFR nimotuzumab antibody drug conjugate (AD...