Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates

• Autori principali: Anjong Florence Tikum (Autore), Anand Krishnan Nambisan (Autore), Jessica Pougoue Ketchemen (Autore), Hanan Babeker (Autore), Musharraf N. Khan (Autore), Emina E. Torlakovic (Autore), Humphrey Fonge (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that bind to different epitopes of domain III of EGFR. We developed ⁸⁹Zr-matuzumab as a PET probe for diagnosis/monitoring of response to treatment of a noncompeting anti-EGFR nimotuzumab antibody drug conjugate (AD...