The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells

• Main Authors: Yixuan Wang (Author), Heng Shen (Author), Qian Sun (Author), Linyao Zhao (Author), Hao Liu (Author), Liguo Ye (Author), Yang Xu (Author), Jiayang Cai (Author), Yuntao Li (Author), Lun Gao (Author), Yinqiu Tan (Author), Baohui Liu (Author), Qianxue Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The most common primary central nervous system tumor in adults is glioblastoma multiforme (GBM). The high invasiveness of GBM cells is an important factor leading to inevitable tumor recurrence and a poor prognosis of patients. GNE-477, a novel PI3K/mTOR inhibitor, has been reported to exert antipro...