An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats

• Main Authors: Colin N. Haile (Author), Miah D. Baker (Author), Sergio A. Sanchez (Author), Carlos A. Lopez Arteaga (Author), Anantha L. Duddupudi (Author), Gregory D. Cuny (Author), Elizabeth B. Norton (Author), Thomas R. Kosten (Author), Therese A. Kosten (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fentanyl (FEN) is a potent synthetic opioid associated with increasing incidence of opioid use disorder (OUD) and fatal opioid overdose. Vaccine immunotherapy for FEN-associated disorders may be a viable therapeutic strategy. Here, we expand and confirm our previous study in mice showing immunologic...