Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

• Main Authors: Emma Jussing (Author), Mélodie Ferrat (Author), Mohammad M. Moein (Author), Henrik Alfredéen (Author), Tetyana Tegnebratt (Author), Klas Bratteby (Author), Erik Samén (Author), Joachim Feldwisch (Author), Renske Altena (Author), Rimma Axelsson (Author), Thuy A. Tran (Author)
• Format: Book
• Published: SpringerOpen, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga). Using the latter, 68Ga, is preferred due to its use in positron emission tomography with...