Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

• Hauptverfasser: Jui-Ling Hsu (Verfasst von), Wohn-Jenn Leu (Verfasst von), Lih-Ching Hsu (Verfasst von), Shih-Ping Liu (Verfasst von), Nan-Shan Zhong (Verfasst von), Jih-Hwa Guh (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Castration-resistant prostate cancer (CRPC) cells can resist many cellular stresses to ensure survival. There is an unmet medical need to fight against the multiple adaptive mechanisms in cells to achieve optimal treatment in patients. Para-toluenesulfonamide (PTS) is a small molecule that inhibited...