Cyclodextrin Inclusion Complexes of Auranofin and Its Iodido Analog: A Chemical and Biological Study

• Main Authors: Damiano Cirri (Author), Ida Landini (Author), Lara Massai (Author), Enrico Mini (Author), Francesca Maestrelli (Author), Luigi Messori (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Auranofin (AF) and its iodido analog, i.e., Au(PEt₃) I (AFI), were reported to exhibit very promising anticancer properties both in vitro and in vivo. However, both these gold compounds have a scarce aqueous solubility that hampers their pharmaceutical use. Here, we explore wh...