Multitarget ligands that comprise opioid/nonopioid pharmacophores for pain management: Current state of the science

• Main Authors: Émile Breault (Author), Michael Desgagné (Author), Jolien De Neve (Author), Jérôme Côté (Author), Thomas M.A. Barlow (Author), Steven Ballet (Author), Philippe Sarret (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic pain, which affects more than one-third of the world's population, represents one of the greatest medical challenges of the 21st century, yet its effective management remains sub-optimal. The 'gold standard' for the treatment of moderate to severe pain consists of opioid ligan...