MicroRNA-206 Downregulation Improves Therapeutic Gene Expression and Motor Function in mdx Mice

• Main Authors: Karen Bulaklak (Author), Bin Xiao (Author), Chunping Qiao (Author), Jianbin Li (Author), Tejash Patel (Author), Quan Jin (Author), Juan Li (Author), Xiao Xiao (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder caused by a mutation in the dystrophin gene. Numerous gene therapies have been developed to replace or repair the defective dystrophin gene; however, these treatments cannot restore the full-length protein or completely resolve dy...