MicroRNA-206 Downregulation Improves Therapeutic Gene Expression and Motor Function in mdx Mice

• Главные авторы: Karen Bulaklak (Автор), Bin Xiao (Автор), Chunping Qiao (Автор), Jianbin Li (Автор), Tejash Patel (Автор), Quan Jin (Автор), Juan Li (Автор), Xiao Xiao (Автор)
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• Опубликовано: Elsevier, 2018-09-01T00:00:00Z.
• Предметы: article
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Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder caused by a mutation in the dystrophin gene. Numerous gene therapies have been developed to replace or repair the defective dystrophin gene; however, these treatments cannot restore the full-length protein or completely resolve dy...