Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

• 主要な著者: Dayma Llanes (著者), Robert Rennert (著者), Paul Jänicke (著者), Ibrahim Morgan (著者), Leslie Reguera (著者), Daniel G. Rivera (著者), Manuel G. Ricardo (著者), Ludger A. Wessjohann (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Peptide-drug conjugates (PDCs) have recently gained significant attention for the targeted delivery of anticancer therapeutics, mainly due to their cost-effective and chemically defined production and lower antigenicity compared to ADCs, among other benefits. In this study, we designed and synthesiz...