Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

• Main Authors: Dayma Llanes (Author), Robert Rennert (Author), Paul Jänicke (Author), Ibrahim Morgan (Author), Leslie Reguera (Author), Daniel G. Rivera (Author), Manuel G. Ricardo (Author), Ludger A. Wessjohann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peptide-drug conjugates (PDCs) have recently gained significant attention for the targeted delivery of anticancer therapeutics, mainly due to their cost-effective and chemically defined production and lower antigenicity compared to ADCs, among other benefits. In this study, we designed and synthesiz...