Study of aversive and p38 mapk-inhibitory properties of kappa-agonist with analgesic activity - compound RU-1205

• Main Authors: Alexander A. Spasov (Author), Edwin E. Zvartau (Author), Olesya Iu. Grechko (Author), Natalya V. Eliseeva (Author), Yuliya V. Semenova (Author), Olga A. Dravolina (Author), Pavel M Vasiliev (Author), Vera A. Anisimova (Author)
• Format: Book
• Published: Belgorod National Research University, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The clinical use of kappa-opioid agonists, despite their lack of significant drug potential, is limited by the development of severe sedation, dysphoria, depression, and anhedonia. To this date, there are kappa-opioid receptor agonists lacking these side effects due to the selective ac...