Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase

• Main Authors: Supreet Kaur (Author), Nicholas S. Nieto (Author), Peter McDonald (Author), Josh R. Beck (Author), Richard B. Honzatko (Author), Anuradha Roy (Author), Scott W. Nelson (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Malaria is caused by infection with protozoan parasites of the Plasmodium genus, which is part of the phylum Apicomplexa. Most organisms in this phylum contain a relic plastid called the apicoplast. The apicoplast genome is replicated by a single DNA polymerase (apPOL), which is an attractive target...