Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase

• Κύριοι συγγραφείς: Supreet Kaur (Συγγραφέας), Nicholas S. Nieto (Συγγραφέας), Peter McDonald (Συγγραφέας), Josh R. Beck (Συγγραφέας), Richard B. Honzatko (Συγγραφέας), Anuradha Roy (Συγγραφέας), Scott W. Nelson (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Malaria is caused by infection with protozoan parasites of the Plasmodium genus, which is part of the phylum Apicomplexa. Most organisms in this phylum contain a relic plastid called the apicoplast. The apicoplast genome is replicated by a single DNA polymerase (apPOL), which is an attractive target...