Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors

Kv1.5 potassium channel, encoded by KCNA5, is a promising target for the treatment of atrial fibrillation, one of the common arrhythmia. A new series of arylmethylpiperidines derivatives based on DDO-02001 were synthesised and evaluated for their ability to inhibit Kv1.5 channel. Among them, compoun...

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Main Authors: Lingyue Zhao (Author), Qian Yang (Author), Yiqun Tang (Author), Qidong You (Author), Xiaoke Guo (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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