Mutation screening of <it>ASMT</it>, the last enzyme of the melatonin pathway, in a large sample of patients with Intellectual Disability

• Main Authors: Tzschach Andreas (Author), Launay Jean-Marie (Author), Delorme Richard (Author), Van Esch Hilde (Author), de Brouwer Arjan (Author), Moreno Sarah (Author), Jamain Stéphane (Author), Dumaine Anne (Author), Poirier Karine (Author), Botros Hany (Author), Pagan Cecile (Author), Kalscheuer Vera (Author), Lacombe Didier (Author), Briault Sylvain (Author), Laumonnier Frédéric (Author), Raynaud Martine (Author), van Bon Bregje W (Author), Willemsen Marjolein H (Author), Leboyer Marion (Author), Chelly Jamel (Author), Bourgeron Thomas (Author)
• 格式: 图书
• 出版: BMC, 2011-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Intellectual disability (ID) is frequently associated with sleep disorders. Treatment with melatonin demonstrated efficacy, suggesting that, at least in a subgroup of patients, the endogenous melatonin level may not be sufficient to...