A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

• Main Authors: Wentworth Sean (Author), Pierson John (Author), Laur Oskar (Author), Gris Denis (Author), Gibson Dustin G (Author), Cheng Philip (Author), Gauthier Josee (Author), Gris Pavel (Author), Nackley Andrea G (Author), Maixner William (Author), Diatchenko Luda (Author)
• Format: Book
• Published: SAGE Publishing, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Opioids are the most widely used analgesics for the treatment of clinical pain. They produce their therapeutic effects by binding to μ-opioid receptors (MORs), which are 7 transmembrane domain (7TM) G-protein-coupled receptors (GPCRs...