RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress

• Main Authors: Er-Chieh Cho (Author), Mei-Ling Kuo (Author), Jia-hui Cheng (Author), Yu-Chi Cheng (Author), Yi-Chen Hsieh (Author), Yun-Ru Liu (Author), Rong-Hong Hsieh (Author), Yun Yen (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly...