Pharmacokinetics of a microdosed cocktail of three direct oral anticoagulants in children with congenital heart defects: study protocol for a single-centre clinical trial (DOAC-Child)

• Автори: Matthias Gorenflo (Автор), Victoria C. Ziesenitz (Автор), Gerd Mikus (Автор), Simon A Hermann (Автор), Kristine Chobanyan-Jürgens (Автор)
• Формат: Книга
• Опубліковано: BMJ Publishing Group, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Introduction Direct oral anticoagulants (DOACs) are direct inhibitors of coagulation factor Xa and are frequently used in adults for different indications such as deep vein thrombosis or non-valvular atrial fibrillation. Paediatric patients might benefit as well from DOACs because the simplicity and...