Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel

• Main Authors: Jian Huang (Author), Ruilin Zhang (Author), Shangwen Wang (Author), Dongxian Zhang (Author), Chi-Kwan Leung (Author), Genmeng Yang (Author), Yuanyuan Li (Author), Liu Liu (Author), Yue Xu (Author), Shucheng Lin (Author), Chan Wang (Author), Xiaofeng Zeng (Author), Juan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synergistic impairment of the blood-brain barrier (BBB) induced by methamphetamine (METH) and HIV-Tat protein increases the risk of HIV-associated neurocognitive disorders (HAND) in HIV-positive METH abusers. Studies have shown that oxidative stress plays a vital role in METH- and HIV-Tat-induced da...