Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the Food and Drug Administration. In this study, we...

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Main Authors: Desislava Yanakieva (Author), Lukas Pekar (Author), Andreas Evers (Author), Markus Fleischer (Author), Stephan Keller (Author), Dirk Mueller-Pompalla (Author), Lars Toleikis (Author), Harald Kolmar (Author), Stefan Zielonka (Author), Simon Krah (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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