A sensitive, simple and rapid HPLCâMS/MS method for simultaneous quantification of buprenorpine and its N-dealkylated metabolite norbuprenorphine in human plasma

• Hauptverfasser: Yi-Ya Wang (Verfasst von), Xiao-Hang Shen (Verfasst von), Hao Li (Verfasst von), Feng-Ju Chen (Verfasst von), Yan Fu (Verfasst von), Li Ding (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2013-08-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

A sensitive, simple and rapid high performance liquid chromatography-tandem mass spectrometry (HPLCâMS/MS) method was developed and fully validated for the simultaneous quantification of buprenorphine (BUP) and its N-dealkylated metabolite norbuprenorphine (NBUP) in 200μL human plasma. Human plasma...