A sensitive, simple and rapid HPLCâMS/MS method for simultaneous quantification of buprenorpine and its N-dealkylated metabolite norbuprenorphine in human plasma

• Main Authors: Yi-Ya Wang (Author), Xiao-Hang Shen (Author), Hao Li (Author), Feng-Ju Chen (Author), Yan Fu (Author), Li Ding (Author)
• Format: Book
• Published: Elsevier, 2013-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A sensitive, simple and rapid high performance liquid chromatography-tandem mass spectrometry (HPLCâMS/MS) method was developed and fully validated for the simultaneous quantification of buprenorphine (BUP) and its N-dealkylated metabolite norbuprenorphine (NBUP) in 200μL human plasma. Human plasma...