Initial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues

• Main Authors: Styliani Xiroudaki (Author), Federica Ianni (Author), Samuele Sabbatini (Author), Elena Roselletti (Author), Claudia Monari (Author), Roccaldo Sardella (Author), Anna Vecchiarelli (Author), Stefano Giovagnoli (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, an initial in vivo evaluation of a new amikacin-deoxycholate hydrophobic salt aimed at potentiating amikacin action against hard-to-treat lung infections was undertaken by quantifying, for the first time, amikacin in whole blood. Pharmacokinetic evaluation after intranasal administrat...