CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

The chemokine (C-C motif) receptor 5 (CCR5) serves as an HIV-1 co-receptor and is essential for cell infection with CCR5-tropic viruses. Loss of functional receptor protects against HIV infection. Here, we report the successful targeting of CCR5 in GFP-marked human induced pluripotent stem cells (iP...

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Main Authors: HyunJun Kang (Author), Petra Minder (Author), Mi Ae Park (Author), Walatta-Tseyon Mesquitta (Author), Bruce E Torbett (Author), Igor I Slukvin (Author)
Format: Book
Published: Elsevier, 2015-01-01T00:00:00Z.
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