Teneligliptin Co-Infusion Alleviates Morphine Tolerance by Inhibition of Spinal Microglial Cell Activation in Streptozotocin-Induced Diabetic Rats

• Auteurs principaux: Yaswanth Kuthati (Auteur), Vaikar Navakanth Rao (Auteur), Wei-Hsiu Huang (Auteur), Prabhakar Busa (Auteur), Chih-Shung Wong (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Morphine (MOR) is a commonly prescribed drug for the treatment of moderate to severe diabetic neuropathic pain (DNP). However, long-term MOR treatment is limited by morphine analgesic tolerance (MAT). The activation of microglial cells and the release of glia-derived proinflammatory cytokines are kn...