Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells

• Main Authors: Nini Cao (Author), Yanyan Lu (Author), Jia Liu (Author), Fangfang Cai (Author), Huangru Xu (Author), Jia Chen (Author), Xiangyu Zhang (Author), Zi-Chun Hua (Author), Hongqin Zhuang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Celecoxib has potential as an effective antineoplastic agent, but it may exhibit side effects. Given the glucose-addicted properties of tumor cells, metformin is recognized for its inhibitory effect on oxidative phosphorylation. In the present study, we aimed to combine low dose of celecoxib with me...