Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis

• Main Authors: Yi Zhang (Author), Binhao Cai (Author), Yingying Li (Author), Ying Xu (Author), Yuhan Wang (Author), Lulu Zheng (Author), Xiaochun Zheng (Author), Lina Yin (Author), Gaozhi Chen (Author), Yunxiang Wang (Author), Guang Liang (Author), Lingfeng Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver fibrosis is characterised by the activation of hepatic stellate cells (HSCs) and matrix deposition. Accumulating evidence has revealed that the oncogenic protein tyrosine phosphatase Src homology 2 domain-containing phosphatase 2 (SHP2) acts as a therapeutic target of fibrosis. Although severa...