Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation

• Main Authors: Jessica R. Dent (Author), Vitor F. Martins (Author), Kristoffer Svensson (Author), Samuel A. LaBarge (Author), Noah C. Schlenk (Author), Mary C. Esparza (Author), Elisa H. Buckner (Author), Gretchen A. Meyer (Author), D. Lee. Hamilton (Author), Simon Schenk (Author), Andrew Philp (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Lysine acetylation is an important post-translational modification that regulates metabolic function in skeletal muscle. The acetyltransferase, general control of amino acid synthesis 5 (GCN5), has been proposed as a regulator of mitochondrial biogenesis via its inhibitory action on perox...