Iron overload favors the elimination of Leishmania infantum from mouse tissues through interaction with reactive oxygen and nitrogen species.

• Main Authors: Sílvia Vale-Costa (Author), Sandra Gomes-Pereira (Author), Carlos Miguel Teixeira (Author), Gustavo Rosa (Author), Pedro Nuno Rodrigues (Author), Ana Tomás (Author), Rui Appelberg (Author), Maria Salomé Gomes (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Iron plays a central role in host-parasite interactions, since both intervenients need iron for survival and growth, but are sensitive to iron-mediated toxicity. The host's iron overload is often associated with susceptibility to infection. However, it has been previously reported that iron ove...