Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits

• Main Authors: Maximilian Bielohuby (Author), Sayyed Hamid Zarkesh-Esfahani (Author), Jenny Manolopoulou (Author), Elisa Wirthgen (Author), Katja Walpurgis (Author), Mohaddeseh Toghiany Khorasgani (Author), Zahra Sadat Aghili (Author), Ian Robert Wilkinson (Author), Andreas Hoeflich (Author), Mario Thevis (Author), Richard J. Ross (Author), Martin Bidlingmaier (Author)
• Format: Book
• Published: The Company of Biologists, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact rodents are of lim...