Clearance of viable Mycobacterium ulcerans from Buruli ulcer lesions during antibiotic treatment as determined by combined 16S rRNA reverse transcriptase /IS 2404 qPCR assay.

• Main Authors: Mabel Sarpong-Duah (Author), Michael Frimpong (Author), Marcus Beissner (Author), Malkin Saar (Author), Ken Laing (Author), Francisca Sarpong (Author), Aloysius Dzigbordi Loglo (Author), Kabiru Mohammed Abass (Author), Margaret Frempong (Author), Fred Stephen Sarfo (Author), Gisela Bretzel (Author), Mark Wansbrough-Jones (Author), Richard Odame Phillips (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Buruli ulcer (BU) caused by Mycobacterium ulcerans is effectively treated with rifampicin and streptomycin for 8 weeks but some lesions take several months to heal. We have shown previously that some slowly healing lesions contain mycolactone suggesting continuing infection after antibiotic therapy....