EEG and Sleep Effects of Tramadol Suggest Potential Antidepressant Effects with Different Mechanisms of Action

• Main Authors: Szabolcs Koncz (Author), Noémi Papp (Author), Noémi Menczelesz (Author), Dóra Pothorszki (Author), György Bagdy (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tramadol is a widely used, centrally acting, opioid analgesic compound, with additional inhibitory effects on the synaptic reuptake of serotonin and noradrenaline, as well as on the 5-HT₂ and NMDA receptors. Preclinical and clinical evidence also suggests its therapeutic poten...