Caffeine Inhibits Oxidative Stress- and Low Dose Endotoxemia-Induced Senescence-Role of Thioredoxin-1

• Main Authors: Dennis Merk (Author), Jan Greulich (Author), Annika Vierkant (Author), Fiona Cox (Author), Olaf Eckermann (Author), Florian von Ameln (Author), Nadine Dyballa-Rukes (Author), Joachim Altschmied (Author), Niloofar Ale-Agha (Author), Philipp Jakobs (Author), Judith Haendeler (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The maintenance of Thioredoxin-1 (Trx-1) levels, and thus of cellular redox homeostasis, is vital for endothelial cells (ECs) to prevent senescence induction. One hallmark of EC functionality, their migratory capacity, which depends on intact mitochondria, is reduced in senescence. Caffeine improves...