Identification of Novel Cyanopyridones and Pyrido[2,3-<em>d</em>]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies

• Main Authors: Tarfah Al-Warhi (Author), Al-Aliaa M. Sallam (Author), Loah R. Hemeda (Author), Mahmoud A. El Hassab (Author), Nada Aljaeed (Author), Ohoud J. Alotaibi (Author), Ahmed S. Doghish (Author), Mina Noshy (Author), Wagdy M. Eldehna (Author), Mona H. Ibrahim (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current work, we designed and synthesized three families of non-fused and fused compounds based on cyanopyridone: derivatives of 6-amino-1,2-dihydropyridine-3,5-dicarbonitrile (<b>5a-f</b>) and 3,4,7,8-tetrahydro pyrimidine-6-carbonitrile (<b>6a-b</b> and <b>7a-e...