Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies

• Main Authors: Amy Easton (Author), Marianne L. Jensen (Author), Congwei Wang (Author), Peter H. Hagedorn (Author), Yuwen Li (Author), Michael Weed (Author), Jere E. Meredith (Author), Valerie Guss (Author), Kelli Jones (Author), Martin Gill (Author), Carol Krause (Author), Jeffrey M. Brown (Author), Lisa Hunihan (Author), Joanne Natale (Author), Alda Fernandes (Author), Yifeng Lu (Author), Joe Polino (Author), Mark Bookbinder (Author), Greg Cadelina (Author), Yulia Benitex (Author), Ramola Sane (Author), John Morrison (Author), Dieter Drexler (Author), Stephen E. Mercer (Author), Charlotte Bon (Author), Nikhil J. Pandya (Author), Ravi Jagasia (Author), Tai-Hsien Ou Yang (Author), Tania Distler (Author), Fiona Grüninger (Author), Michael Meldgaard (Author), Marco Terrigno (Author), John E. Macor (Author), Charles F. Albright (Author), James Loy (Author), Anja M. Hoeg (Author), Richard E. Olson (Author), Angela M. Cacace (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of hyperphosphorylated, aggregated tau. Because tau pathology can be distinct across diseases, a pragmatic therapeutic approach m...