Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

• Main Authors: Andrew C Sayce (Author), Dominic S Alonzi (Author), Sarah S Killingbeck (Author), Beatrice E Tyrrell (Author), Michelle L Hill (Author), Alessandro T Caputo (Author), Ren Iwaki (Author), Kyoko Kinami (Author), Daisuke Ide (Author), J L Kiappes (Author), P Robert Beatty (Author), Atsushi Kato (Author), Eva Harris (Author), Raymond A Dwek (Author), Joanna L Miller (Author), Nicole Zitzmann (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a diverse spectrum of viruses, including dengue vir...