Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse.

• Main Authors: Pei-Ju Liu (Author), Yao-Shen Chen (Author), Hsi-Hsu Lin (Author), Wei-Feng Ni (Author), Tsung-Han Hsieh (Author), Hsu-Tzu Chen (Author), Ya-Lei Chen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Approximately 3-5% of patients with melioidosis manifest CNS symptoms; however, the clinical data regarding neurological melioidosis are limited. METHODS AND FINDINGS: We established a mouse model of melioidosis with meningitis characterized by neutrophil infiltration into the meninges h...