Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse.

• Автори: Pei-Ju Liu (Автор), Yao-Shen Chen (Автор), Hsi-Hsu Lin (Автор), Wei-Feng Ni (Автор), Tsung-Han Hsieh (Автор), Hsu-Tzu Chen (Автор), Ya-Lei Chen (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

BACKGROUND: Approximately 3-5% of patients with melioidosis manifest CNS symptoms; however, the clinical data regarding neurological melioidosis are limited. METHODS AND FINDINGS: We established a mouse model of melioidosis with meningitis characterized by neutrophil infiltration into the meninges h...