Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis

• Main Authors: Matteo Puccetti (Author), Giuseppe Paolicelli (Author), Vasileios Oikonomou (Author), Antonella De Luca (Author), Giorgia Renga (Author), Monica Borghi (Author), Marilena Pariano (Author), Claudia Stincardini (Author), Lucia Scaringi (Author), Stefano Giovagnoli (Author), Maurizio Ricci (Author), Luigina Romani (Author), Teresa Zelante (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon...